Cloning and sequence analysis of a cDNA encoding human syntaxin 1A, a polypeptide essential for exocytosis

Gene. 1995 Jul 4;159(2):293-4. doi: 10.1016/0378-1119(95)00152-v.

Abstract

A clone encoding human syntaxin 1A was isolated and sequenced from a human brain library. The deduced sequence encodes a 288-amino-acid (aa) protein that presumably plays a critical role in neurotransmitter exocytosis and is 98.0% identical to the aa sequence of rat syntaxin 1A.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Antigens, Surface / genetics*
  • Base Sequence
  • Biological Transport
  • Brain Chemistry / genetics*
  • Exocytosis
  • Gene Library
  • Humans
  • Membrane Proteins / genetics*
  • Molecular Sequence Data
  • Nerve Tissue Proteins / genetics*
  • Neurotransmitter Agents / metabolism
  • Qa-SNARE Proteins
  • Sequence Homology, Amino Acid
  • Species Specificity
  • Syntaxin 1

Substances

  • Antigens, Surface
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Neurotransmitter Agents
  • Qa-SNARE Proteins
  • STX1A protein, human
  • Stx1a protein, rat
  • Syntaxin 1

Associated data

  • GENBANK/L37792