Abstract
Cytotoxicity-directed fractionation of an organic extract of the tunicate Lissoclinum patella afforded a new cyclic octapeptide, patellamide F [1]. The structure and absolute stereochemistry of 1 were established by a combination of spectroscopic and chemical methods. Three known cyclic peptides, patellamide B [2], ulithiacyclamide, and lissoclinamide 3, were also isolated and identified.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / isolation & purification
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Drug Screening Assays, Antitumor
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Humans
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Hydrolysis
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Magnetic Resonance Spectroscopy
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Ozone / chemistry
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Peptides, Cyclic / chemistry*
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Peptides, Cyclic / isolation & purification
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Spectrometry, Mass, Fast Atom Bombardment
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Tumor Cells, Cultured
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Urochordata / chemistry*
Substances
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Antineoplastic Agents
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Peptides, Cyclic
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patellamide F
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Ozone