Studies on the inhibitory effects of caffeoylquinic acids on monocyte migration and superoxide ion production

G Peluso; V De Feo; F De Simone; E Bresciano; M L Vuotto

doi:10.1021/np50119a001

Studies on the inhibitory effects of caffeoylquinic acids on monocyte migration and superoxide ion production

J Nat Prod. 1995 May;58(5):639-46. doi: 10.1021/np50119a001.

Authors

G Peluso¹, V De Feo, F De Simone, E Bresciano, M L Vuotto

Affiliation

¹ Istituto di Biochimica delle Proteine ed Enzimologia, Napoli, Italy.

PMID: 7623043
DOI: 10.1021/np50119a001

Abstract

Three caffeoylquinic acids, isolated from the Peruvian plants Tessaria integrifolia and Mikania cordifolia that are used medicinally as anti-inflammatory agents, were tested for their activities on monocyte migration and superoxide anion production. 3,5-Di-O-caffeoylquinic and 4,5-di-O-caffeoylquinic acids exhibited an appreciable anti-inflammatory activity in vitro, while the tricaffeoyl derivative was inactive.

MeSH terms

Amino Acid Sequence
Cells, Cultured
Chemotaxis, Leukocyte / drug effects*
Humans
Molecular Sequence Data
Monocytes / cytology
Monocytes / drug effects*
Monocytes / metabolism
N-Formylmethionine Leucyl-Phenylalanine / pharmacology
Plants, Medicinal* / cytology
Quinic Acid / analogs & derivatives
Quinic Acid / isolation & purification
Quinic Acid / pharmacology*
Superoxides / metabolism*

Substances

Quinic Acid
Superoxides
N-Formylmethionine Leucyl-Phenylalanine