Effectiveness of the combination verapamil and chlorpromazine in the treatment of severe manic or mixed patients

Prog Neuropsychopharmacol Biol Psychiatry. 1995 May;19(3):519-28. doi: 10.1016/0278-5846(95)00033-r.


1. The authors investigated the possible antimanic properties of a Calcium channel blocker, Verapamil, in 15 in-patients admitted consecutively to the female psychiatric ward at Pisa University for a manic episode. 2. The results showed that most of the patients presented a global improvement of the manic symptoms and, in some cases, even a complete clinical remission. 3. Although it was necessary to add chlorpromazine for the severe conditions of several patients, verapamil appeared to speed the positive outcome and to lead to a faster resolution of the symptoms. In addition, the association of verapamil and chlorpromazine did not produce any relevant side-effect. These preliminary findings thus indicate that verapamil by itself does not seem to be sufficient in the treatment of a severe affective episode, but it may constitute an alternative to lithium salts in association with neuroleptics.

Publication types

  • Case Reports
  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Bipolar Disorder / drug therapy*
  • Bipolar Disorder / psychology
  • Chlorpromazine / therapeutic use*
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Female
  • Hospitalization
  • Humans
  • Middle Aged
  • Psychiatric Status Rating Scales
  • Time Factors
  • Treatment Outcome
  • Verapamil / therapeutic use*


  • Verapamil
  • Chlorpromazine