Poliomyelitis-like illness after acute asthma (Hopkins syndrome): a histological study of biopsied muscle in a case

Brain Dev. 1995 Mar-Apr;17(2):126-9. doi: 10.1016/0387-7604(94)00125-h.


A case of Hopkins syndrome is presented. The patient was a 4-year-old boy who developed weakness of the right leg 2-3 days after a mild asthmatic attack. Needle electromyography revealed fasciculation discharges in the right gastrocnemius muscle. A histological study of the biopsied right quadriceps femoris muscle revealed scattered atrophic fibers, indicating lesions in the anterior horn cells of the spinal cord. This is the first reported case of Hopkins syndrome including muscle pathology.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Asthma / complications*
  • Asthma / pathology
  • Biopsy
  • Child, Preschool
  • Electromyography
  • Fasciculation
  • Female
  • Humans
  • Male
  • Muscle Fibers, Skeletal / pathology
  • Muscle, Skeletal / pathology*
  • Muscle, Skeletal / physiopathology
  • Muscular Atrophy / complications
  • Muscular Atrophy / pathology*
  • Muscular Atrophy / physiopathology*