Early detection of catabolic state via change in 13C/12C ratios of blood proteins

Biochem Biophys Res Commun. 1995 Jul 26;212(3):719-26. doi: 10.1006/bbrc.1995.2030.


We find that induction of catabolic state changes the ratios of carbon 13 to carbon 12 in blood proteins. Diet can be inferred in growing chicks by feather carbon isotope ratios. This suggests an approach for early detection of catabolic state induced in patients with HIV, cancers that induce catabolism, infection onset, sepsis, kidney and liver disease, malnutrition and dietary problems. The technique would also be useful in animal husbandry.

MeSH terms

  • Animals
  • Blood Proteins / chemistry*
  • Blood Proteins / metabolism*
  • Carbon / analysis*
  • Carbon Isotopes*
  • Chickens
  • Diet
  • Feathers / chemistry
  • Feathers / growth & development
  • Female
  • Hemoglobins / chemistry
  • Hemoglobins / metabolism
  • Humans
  • Male


  • Blood Proteins
  • Carbon Isotopes
  • Hemoglobins
  • Carbon