Androgen induction of follicular epithelial cell growth is mediated via insulin-like growth factor-I from dermal papilla cells

Biochem Biophys Res Commun. 1995 Jul 26;212(3):988-94. doi: 10.1006/bbrc.1995.2067.

Abstract

Androgen significantly stimulates the proliferation of outer root sheath cells that are cocultured with beard dermal papilla cells without cell contact. The expression of insulin-like growth factor I (IGF-I) mRNA in beard dermal papilla cells was stimulated by androgen and antagonized by cyproterone acetate. Outer root sheath cells did not express mRNA for IGF-I either in the presence or absence of androgen. Both of these two types of cells expressed mRNA for IGF-I receptor and the expression was not affected by androgen. Neutralizing antibody against IGF-I antagonized the stimulatory effect of androgen on the growth of outer root sheath cell cocultured with beard dermal papilla cells. These findings suggest that IGF-I is a candidate for androgen induced hair growth factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies
  • Base Sequence
  • Cell Division / drug effects
  • Cells, Cultured
  • Cyproterone Acetate / pharmacology
  • DNA Primers / genetics
  • Epithelial Cells
  • Epithelium / drug effects
  • Epithelium / metabolism
  • Hair / cytology
  • Hair / drug effects*
  • Hair / metabolism*
  • Humans
  • Insulin-Like Growth Factor I / antagonists & inhibitors
  • Insulin-Like Growth Factor I / genetics
  • Insulin-Like Growth Factor I / metabolism*
  • Metribolone / pharmacology*
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism

Substances

  • Antibodies
  • DNA Primers
  • RNA, Messenger
  • Metribolone
  • Cyproterone Acetate
  • Insulin-Like Growth Factor I