Chromosome 12 abnormalities in malignant ovarian germ cell tumors

E Rodriguez; J Melamed; V Reuter; R S Chaganti

doi:10.1016/0165-4608(95)00067-y

Chromosome 12 abnormalities in malignant ovarian germ cell tumors

Cancer Genet Cytogenet. 1995 Jul 1;82(1):62-6. doi: 10.1016/0165-4608(95)00067-y.

Authors

E Rodriguez¹, J Melamed, V Reuter, R S Chaganti

Affiliation

¹ Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

PMID: 7627937
DOI: 10.1016/0165-4608(95)00067-y

Abstract

We analyzed 3 cases of malignant ovarian germ cell tumors (MOGCTs), comprising 1 dysgerminoma and 2 immature teratomas, by banded chromosome analysis and by in situ hybridization (ISH) using a chromosome 12p painting probe. We found evidence of 12p abnormalities in two of them. A possible common genetic pathway of origin of a subset of MOGCTs with testicular germ cell tumors (TGCTs) is discussed.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Aneuploidy
Chromosome Aberrations / pathology*
Chromosome Banding
Chromosome Disorders
Chromosomes, Human, Pair 12*
Dysgerminoma / pathology*
Female
Humans
In Situ Hybridization, Fluorescence
Ovarian Neoplasms / pathology*
Teratoma / pathology*

Abstract

Publication types

MeSH terms

Grants and funding