Effects of delta-sleep inducing peptide (DSIP) and some analogues on the activity of monoamine oxidase type A in rat brain under hypoxia stress

E M Khvatova; N A Rubanova; I A Prudchenko; I I Mikhaleva

doi:10.1016/0014-5793(95)00661-r

Effects of delta-sleep inducing peptide (DSIP) and some analogues on the activity of monoamine oxidase type A in rat brain under hypoxia stress

FEBS Lett. 1995 Jul 17;368(2):367-9. doi: 10.1016/0014-5793(95)00661-r.

Authors

E M Khvatova¹, N A Rubanova, I A Prudchenko, I I Mikhaleva

Affiliation

¹ Nizhnii Novgorod Medical Academy, Russian Federation.

PMID: 7628639
DOI: 10.1016/0014-5793(95)00661-r

Abstract

Metabolic effects of delta-sleep inducing peptide (DSIP) under hypoxia stress were investigated in rats subjected to short-term hypoxic conditions (about 0.26 Bar). It was found that DSIP partially restricted stress-induced changes in activity of mitochondrial monoamine oxidase type A (MAO-A) and serotonin level in rat brain. A number of DSIP analogues was tested and among them there were some compounds with enhanced ability to counteract hypoxia induced changes in MAO-A activity and serotonin content in comparison with native neuropeptide.

MeSH terms

Amino Acid Sequence
Animals
Brain Chemistry / drug effects*
Cytoplasm / enzymology
Delta Sleep-Inducing Peptide / analogs & derivatives
Delta Sleep-Inducing Peptide / chemical synthesis
Delta Sleep-Inducing Peptide / pharmacology*
Hypoxia / enzymology*
Male
Mitochondria / enzymology
Molecular Sequence Data
Monoamine Oxidase / metabolism*
Rats
Serotonin / analysis

Substances

Serotonin
Delta Sleep-Inducing Peptide
Monoamine Oxidase