Urinary albumin excretion is associated with the intima-media thickness of the carotid artery in hypertensive males with non-insulin-dependent diabetes mellitus

J Hypertens. 1995 Apr;13(4):463-9.


Objective: To examine the relationship between urinary albumin excretion and ultrasonographically assessed morphology of the common carotid artery in hypertensive men with and without non-insulin-dependent diabetes mellitus.

Design: Cross-sectional study.

Setting: An outpatient clinic in a city hospital.

Patients: Hypertensive male patients (n = 25) with non-insulin-dependent diabetes mellitus and non-diabetic hypertensive male patients (n = 94) aged 50-72 years, randomly selected from a larger study group.

Main outcome measures: Overnight urinary albumin excretion and B-mode ultrasound examinations of the carotid artery.

Results: Among the diabetic patients the logarithm of the overnight urinary albumin excretion was independently and significantly associated with the common carotid artery intima-media thickness, which was also true after adjustment for concomitant cardiovascular disease. In the non-diabetic group there was no association between intima-media thickness and urinary albumin excretion. No relationship between the occurrence of plaque and urinary albumin excretion was observed in any of the study groups. The results were reproducible at a re-examination after 3 years using the same methods.

Conclusion: Among the hypertensive men with non-insulin-dependent diabetes mellitus, an independent and significant relationship, reproducible after 3 years, was found between urinary albumin excretion and the intima-media thickness of the common carotid artery. No such relationship was found in the group of non-diabetic hypertensive males.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Albuminuria / complications*
  • Antihypertensive Agents / therapeutic use
  • Arteriosclerosis / complications*
  • Arteriosclerosis / pathology
  • Blood Pressure / drug effects
  • Carotid Arteries / diagnostic imaging
  • Carotid Arteries / pathology*
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2 / complications*
  • Humans
  • Hypertension / complications*
  • Hypertension / drug therapy
  • Hypertension / pathology*
  • Male
  • Middle Aged
  • Regression Analysis
  • Risk Factors
  • Surveys and Questionnaires
  • Ultrasonography


  • Antihypertensive Agents