[Abnormal expression of E-cadherin in human pancreatic carcinoma cell lines]

Nihon Rinsho. 1995 Jul;53(7):1595-601.
[Article in Japanese]

Abstract

Nineteen human pancreatic cancer cell lines were analyzed for possible abnormal mRNA and/or protein expression of the E-cadherin. Five lines showed no or markedly reduced expression of the E-cadherin, and protein was absent. In 9 lines, mRNA was positive but protein distribution was abnormal, i.e. diffusely positive in cytoplasm instead of membrane, or mixed distribution to membrane and cytoplasm. These 14 cell lines with abnormal E-cadherin expression grow in isolated fashion or loose sheet formation, indicating the loss of cell-cell adhesion system. These findings that the strong relation between E-cadherin abnormalities and loss of physical cell-cell interaction may explain the extensively poor prognosis of the patients with pancreatic carcinoma.

Publication types

  • English Abstract

MeSH terms

  • Cadherins / genetics
  • Cadherins / metabolism*
  • Cytoskeletal Proteins / metabolism
  • Humans
  • Pancreatic Neoplasms / genetics
  • Pancreatic Neoplasms / metabolism*
  • RNA, Messenger / analysis*
  • Trans-Activators*
  • Tumor Cells, Cultured
  • alpha Catenin
  • beta Catenin

Substances

  • CTNNA1 protein, human
  • CTNNB1 protein, human
  • Cadherins
  • Cytoskeletal Proteins
  • RNA, Messenger
  • Trans-Activators
  • alpha Catenin
  • beta Catenin