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, 376 (6538), 313-20

Mechanism of CDK Activation Revealed by the Structure of a cyclinA-CDK2 Complex

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Mechanism of CDK Activation Revealed by the Structure of a cyclinA-CDK2 Complex

P D Jeffrey et al. Nature.

Abstract

The crystal structure of the human cyclinA-cyclin-dependent kinase2 (CDK2)-ATP complex has been determined at 2.3 A resolution. CyclinA binds to one side of CDK2's catalytic cleft, inducing large conformational changes in its PSTAIRE helix and T-loop. These changes activate the kinase by realigning active site residues and relieving the steric blockade at the entrance of the catalytic cleft.

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