Improved immunogenicity of oral D x RRV reassortant rotavirus vaccine by Lactobacillus casei GG

Vaccine. 1995 Feb;13(3):310-2. doi: 10.1016/0264-410x(95)93319-5.

Abstract

In a search for new strategies to improve oral vaccination, the effect of orally administered Lactobacillus casei strain GG (LGG) in conjunction with D x RRV rhesus-human reassortant live oral rotavirus vaccine was tested in 2-5-month-old infants. Infants who received LGG showed an increased response with regard to rotavirus-specific IgM secreting cells, measured using an ELISPOT technique, on day 8 after vaccination. In infants receiving LGG or placebo, respectively, a rotavirus IgM seroconversion was detected in 26/27 (96%), versus 23/27 (85%) cases (p = 0.15) and rotavirus IgA seroconversion was detected in 26/28 (93%) versus 20/27 (74%) cases (p = 0.05). These findings suggest that LGG has an immunostimulating effect on oral rotavirus vaccination. The clinical significance of LGG-enhanced immune responses to oral vaccines should be further evaluated.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Administration, Oral
  • Animals
  • Antibodies, Viral / biosynthesis
  • Diarrhea / prevention & control
  • Diarrhea / virology
  • Enzyme-Linked Immunosorbent Assay
  • Follow-Up Studies
  • Humans
  • Immunoglobulin A / biosynthesis
  • Immunoglobulin G / biosynthesis
  • Immunoglobulin M / biosynthesis
  • Infant
  • Lactobacillus casei / immunology*
  • Rotavirus / immunology*
  • Rotavirus Infections / prevention & control
  • Viral Vaccines / administration & dosage*
  • Viral Vaccines / immunology*

Substances

  • Antibodies, Viral
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M
  • Viral Vaccines