Prediction of acute coronary syndromes by percutaneous coronary angioscopy in patients with stable angina

Am Heart J. 1995 Aug;130(2):195-203. doi: 10.1016/0002-8703(95)90429-8.


To pinpoint the link between plaque characteristics and acute coronary syndromes, we performed a 12-month prospective follow-up study in 157 patients with stable angina pectoris in whom regular coronary plaques were observed by percutaneous coronary angioscopy. Acute coronary syndromes occurred more frequently in patients with yellow plaque than in those with white plaques (11 of 39 vs 4 of 118; p = 0.00021). Moreover, the syndromes occurred more frequently in patients with glistening yellow plaques than in those with nonglistening yellow plaques (9 of 13 vs 2 of 26; p = 0.00026). Thrombus arising from the ruptured identical plaques was confirmed by angioscopy as the culprit lesion of the syndromes. The results indicate that acute coronary syndromes occur frequently and in a short time in patients with glistening yellow plaques and that angioscopy but not angiography is feasible for prediction of the syndromes.

Publication types

  • Clinical Trial

MeSH terms

  • Acute Disease
  • Adult
  • Aged
  • Angina Pectoris / diagnostic imaging
  • Angina Pectoris / pathology*
  • Angina, Unstable / diagnosis*
  • Angina, Unstable / pathology
  • Angioscopy* / methods
  • Coronary Angiography
  • Coronary Artery Disease / diagnostic imaging
  • Coronary Artery Disease / pathology*
  • Coronary Thrombosis / diagnosis
  • Coronary Vessels / pathology*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction / diagnosis*
  • Myocardial Infarction / pathology
  • Predictive Value of Tests
  • Prognosis
  • Prospective Studies
  • Syndrome