Carotid artery plaque composition--relationship to clinical presentation and ultrasound B-mode imaging. European Carotid Plaque Study Group

Eur J Vasc Endovasc Surg. 1995 Jul;10(1):23-30. doi: 10.1016/s1078-5884(05)80194-7.


Objective: To correlate B-mode ultrasound findings to carotid plaque histology.

Design: European multicentre study (nine centres).

Material and methods: Clinical presentation and risk factors were recorded and preoperative ultrasound Duplex scanning with special emphasis on B-mode imaging studies was performed in 270 patients undergoing carotid endarterectomy. Perioperatively, macroscopic plaque features were evaluated and the removed specimens were analysed histologically for fibrous tissue, calcification and 'soft tissue' (primarily haemorrhage and lipid).

Results: Males had more soft tissue than females (p = 0.0006), hypertensive patients less soft tissue than normotensive (p = 0.01) and patients with recent symptoms more soft tissue than patients with earlier symptoms (p = 0.004). There was no correlation between surface description on ultrasound images compared to the surface judged intraoperatively by the surgeon. Echogenicity on B-mode images was inversely related to soft tissue (p = 0.005) and calcification was directly related to echogenicity (p < 0.0001). Heterogeneous plaques contained more calcification than homogeneous (p = 0.003), however, there was no difference in content of soft tissue.

Conclusion: Ultrasound B-mode characteristics are related to the histological composition of carotid artery plaques and to patient's history. These results may imply that patients with distant symptoms may be regarded and treated as asymptomatic patients whereas asymptomatic patients with echolucent plaques should be considered for carotid endarterectomy.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Arteriosclerosis / diagnostic imaging
  • Arteriosclerosis / pathology*
  • Arteriosclerosis / surgery
  • Carotid Artery, Common / diagnostic imaging
  • Carotid Artery, Common / pathology
  • Carotid Artery, Internal / diagnostic imaging
  • Carotid Artery, Internal / pathology
  • Carotid Stenosis / diagnostic imaging
  • Carotid Stenosis / pathology*
  • Carotid Stenosis / surgery
  • Endarterectomy, Carotid
  • Female
  • Humans
  • Male
  • Middle Aged
  • Ultrasonography