In two independent studies, 0.125% amitraz solution applied half-body daily was found 73% effective in curing dogs with demodicosis previously refractory to biweekly or weekly amitraz treatments. Thirteen of the 16 cases that resolved did so after one course of treatment which ranged from four weeks to five months in duration. The other three cases initially relapsed but then were cured after they were re-treated. All cases deemed cured, including those that initially relapsed, were followed for at least one year after their last treatment.