The basal level of transcription of the alc genes in the ethanol regulon in Aspergillus nidulans is controlled both by the specific transactivator AlcR and the general carbon catabolite repressor CreA

FEBS Lett. 1995 Jul 24;368(3):547-50. doi: 10.1016/0014-5793(95)00736-s.


In the A. nidulans ethanol utilization pathway, specific induction is mediated by the transactivator AlcR which is subject to strong positive autogenous regulation and activates the transcription of the two structural genes alcA and aldA. Carbon catabolite repression is mediated by CreA which represses directly the transacting gene alcR and the two structural genes. We show here that the basal expression of the alcR and alcA genes is also controlled by the two regulatory circuits, positively by the transactivator AlcR and negatively by the repressor CreA, the aldA gene being subject only to the control of the CreA repressor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus nidulans / genetics*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Ethanol / metabolism*
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism*
  • Gene Expression Regulation, Fungal
  • Genes, Fungal
  • Regulon*
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism*
  • Trans-Activators / metabolism
  • Transcription, Genetic*


  • ALCR protein, Aspergillus nidulans
  • DNA-Binding Proteins
  • Fungal Proteins
  • Repressor Proteins
  • Trans-Activators
  • CreA protein, Aspergillus nidulans
  • Ethanol