Inhaled nitric oxide in anesthesia and critical care medicine

Int Anesthesiol Clin. 1995 Winter;33(1):181-210.


Inhaled NO is an exciting new drug and has enormous potential in the therapy of a wide variety of acute, and possibly chronic, cardiopulmonary disorders. No reports of controlled, randomized, and blinded trials have been published concerning the use of inhaled NO in any clinical condition. In the United States, use of inhaled NO currently requires an investigational new drug approval from the Food and Drug Administration. Physicians involved in anesthesia and critical care medicine have a unique opportunity to validate a new mode of therapy in acute care, and optimal evaluation should be undertaken so that the real therapeutic role of inhaled NO may be defined.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Administration, Inhalation
  • Adult
  • Anesthesia, Inhalation*
  • Anesthetics, Inhalation* / pharmacology
  • Child
  • Critical Care*
  • Drug Approval
  • Humans
  • Nitric Oxide* / adverse effects
  • Nitric Oxide* / pharmacology
  • Nitric Oxide* / therapeutic use
  • Vasodilator Agents / administration & dosage
  • Vasodilator Agents / therapeutic use


  • Anesthetics, Inhalation
  • Vasodilator Agents
  • Nitric Oxide