Myositis and fasciitis associated with group A beta hemolytic streptococcal infections: development of a rabbit model

J Lab Clin Med. 1995 Aug;126(2):137-43.

Abstract

Group A streptococci produce a variety of clinical symptoms ranging from minor pharyngeal infections to life-threatening soft-tissue disease. A rabbit model is described for induction of myonecrosis and fasciitis with group A beta-hemolytic streptococci. Group A streptococcal infections have shown remarkable virulence in recent years, resulting in severe local tissue destruction and life-threatening toxicity. After subcutaneous injection into the thigh of 20 ml broth containing 10(5) to 10(9) cfu/ml, initial soft tissue infection rapidly progressed to rhabdomyolysis. The response of the rabbits to the infection was consistent with the human response.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Animals
  • Body Temperature / physiology
  • Cell Count
  • Disease Models, Animal*
  • Fasciitis / complications*
  • Fasciitis / microbiology
  • Fasciitis / physiopathology
  • Humans
  • Lymphocytes / cytology
  • Male
  • Muscle, Skeletal / pathology
  • Myositis / complications*
  • Myositis / microbiology
  • Myositis / physiopathology
  • Necrosis
  • Rabbits*
  • Streptococcal Infections / complications*
  • Streptococcal Infections / pathology
  • Streptococcal Infections / physiopathology
  • Streptococcus pyogenes*
  • Time Factors