Chromophobe cell renal carcinoma: clinicopathological features of 50 cases

J Urol. 1995 Sep;154(3):964-7. doi: 10.1016/s0022-5347(01)66944-1.


Purpose: We review the clinicopathological features of chromophobe cell renal carcinoma.

Materials and methods: Cases were identified by reviewing the histology of all renal neoplasms resected between 1977 and 1990. Clinical data were obtained by chart review.

Results: Of 50 cases a majority (53%) were discovered incidentally and most (86%) were stage I. Typical pathological findings included the presence of 2 cell types (pale and eosinophilic), reactivity for Hale's colloidal iron, ultrastructural cytoplasmic vesicles and deoxyribonucleic acid aneuploidy. At last followup 47 patients (94%) were tumor-free or dead of unrelated causes. Survival was similar in patients with clear cell carcinoma of similar grade and stage.

Conclusions: Chromophobe cell carcinoma is a morphologically distinctive neoplasm with a favorable prognosis. Distinction from renal oncocytoma is important.

MeSH terms

  • Adenocarcinoma / mortality
  • Adenocarcinoma / pathology*
  • Adenocarcinoma, Clear Cell / mortality
  • Adult
  • Aged
  • Aged, 80 and over
  • Aneuploidy
  • DNA, Neoplasm / analysis
  • Female
  • Humans
  • Kidney Neoplasms / mortality
  • Kidney Neoplasms / pathology*
  • Male
  • Middle Aged
  • Prognosis
  • Survival Rate


  • DNA, Neoplasm