Calbindin D28k mRNA in hippocampus, superior temporal gyrus and cerebellum: comparison between control and Alzheimer disease subjects

Brain Res Mol Brain Res. 1995 Jun;30(2):362-6. doi: 10.1016/0169-328x(95)00035-q.


To further investigate the role of calbindin D28k in Alzheimer's disease (AD); hippocampus, superior temporal gyrus and cerebellum from control and AD cases were examined by quantitative in situ hybridization. We report here a decrease in CaBD28k mRNA in the CA2 region of AD hippocampus compared to control subjects. There were no significant differences between AD and control subjects in the other regions studied.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Alzheimer Disease / metabolism*
  • Calbindin 1
  • Calbindins
  • Cerebellum / metabolism
  • Female
  • Hippocampus / metabolism*
  • Humans
  • Male
  • Middle Aged
  • Nerve Tissue Proteins / metabolism*
  • RNA, Messenger / metabolism*
  • S100 Calcium Binding Protein G / metabolism*
  • Temporal Lobe / metabolism


  • CALB1 protein, human
  • Calbindin 1
  • Calbindins
  • Nerve Tissue Proteins
  • RNA, Messenger
  • S100 Calcium Binding Protein G