Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein

Brain Res Mol Brain Res. 1995 Jun;30(2):381-4. doi: 10.1016/0169-328x(95)00029-r.


The hippocampal cholinergic neurostimulating peptide (HCNP) enhances acetylcholine synthesis in rat medial septal tissues. We have cloned the cDNAs of the precursor proteins of rat and human HCNP and deduced their respective amino acid sequences. The HCNP sequences aligned at the N-terminal regions of their precursors. The deduced amino acid sequences showed homology with those of the bovine brain phosphatidylethanolamine-binding protein and the rat protein associated with the opioid-binding protein. These observations suggest that the HCNP precursor proteins may have multiple functions.

MeSH terms

  • Acetylcholine / biosynthesis
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Carrier Proteins / genetics*
  • Cattle
  • Cholinergic Agents / metabolism*
  • DNA, Complementary
  • Humans
  • Molecular Sequence Data
  • Neuropeptides / genetics
  • Neuropeptides / metabolism*
  • Phosphatidylethanolamines / metabolism*
  • Protein Precursors / metabolism*
  • Rats
  • Receptors, Opioid / metabolism*


  • Carrier Proteins
  • Cholinergic Agents
  • DNA, Complementary
  • Neuropeptides
  • Phosphatidylethanolamines
  • Protein Precursors
  • Receptors, Opioid
  • hippocampal cholinergic neurostimulating peptide
  • Acetylcholine

Associated data

  • GENBANK/X75252
  • GENBANK/X75253
  • PIR/S00056