Prolonged expression of Fos-related antigens, Jun B and TrkB in dopamine-denervated striatal neurons

Brain Res Mol Brain Res. 1995 Jun;30(2):393-6. doi: 10.1016/0169-328x(95)00037-s.


Previous studies have demonstrated that striatal dopamine-denervation leads to a long-term increase in Fos-related antigen(s) (FRA's) in striatal neurons. Because Fos-family proteins bind to DNA by dimerizing to Jun-family proteins we investigated the expression of Jun B protein 2 weeks and 1 month after striatal dopamine-denervation, produced by medial forebrain bundle transection. We also investigated the effects of this lesion on TrkB-immunoreactivity in the striatum. FRA's (as previously reported) and Jun B were expressed in striatal neurons following dopamine-denervation, and in addition, there was an increase in expression of TrkB in the striatum on the dopamine-denervated side. These results show that striatal dopamine depletion leads to a long-term up-regulation of FRA's and Jun B in the striatum, and this may be related to other biochemical changes previously reported to occur in striatal neurons (e.g.: D2-dopamine receptor up-regulation) after dopamine depletion. In addition, FRA and Jun B expression may induce increased production of TrkB after dopamine-denervation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens / genetics*
  • Corpus Striatum / cytology
  • Corpus Striatum / metabolism*
  • Dopamine / metabolism
  • Gene Expression
  • Male
  • Protein Kinases / biosynthesis
  • Proto-Oncogene Proteins c-fos / biosynthesis*
  • Proto-Oncogene Proteins c-jun / biosynthesis*
  • Rats
  • Rats, Wistar
  • Tyrosine 3-Monooxygenase / immunology
  • Up-Regulation


  • Antigens
  • Proto-Oncogene Proteins c-fos
  • Proto-Oncogene Proteins c-jun
  • Tyrosine 3-Monooxygenase
  • Protein Kinases
  • Dopamine