Modulation of memory fields by dopamine D1 receptors in prefrontal cortex

Nature. 1995 Aug 17;376(6541):572-5. doi: 10.1038/376572a0.


Dopamine has been implicated in the cognitive process of working memory but the cellular basis of its action has yet to be revealed. By combining iontophoretic analysis of dopamine receptors with single-cell recording during behaviour, we found that D1 antagonists can selectively potentiate the 'memory fields' of prefrontal neurons which subserve working memory. The precision shown for D1 receptor modulation of mnemonic processing indicates a direct gating of selective excitatory synaptic inputs to prefrontal neurons during cognition.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Haplorhini
  • Iontophoresis
  • Memory / physiology*
  • Neurons / physiology
  • Prefrontal Cortex / physiology*
  • Psychomotor Performance
  • Receptors, Dopamine D1 / antagonists & inhibitors
  • Receptors, Dopamine D1 / physiology*
  • Receptors, Dopamine D2 / physiology


  • Receptors, Dopamine D1
  • Receptors, Dopamine D2