Fetal tissue dosages of retinoids. Experimental study concerning a case of isotretinoin (Roaccutan) administration and pregnancy

Fetal Diagn Ther. 1995 May-Jun;10(3):189-91. doi: 10.1159/000264234.


The authors report the case of a women who took retinoids (Roaccutan, isotretinoin) during the first trimester of pregnancy, and a therapeutic abortion was carried out. The interest in this case report lies in the determination of the concentration of isotretinoin and its metabolites (4-oxo-isotretinoin, and tretinoin) in fetal tissues, using high performance liquid chromatography. The findings show the significant transplacental crossing of isotretinoin, an accumulation of 4-oxo-isotretinoin in the liver, and a low concentration of retinoids in the brain of this 4-month-old fetus. The authors emphasize that contraception must be used during retinoid treatment, and 4 weeks after retinoids have been stopped.

MeSH terms

  • Abortion, Therapeutic
  • Acne Vulgaris / drug therapy
  • Brain / metabolism
  • Female
  • Fetus / metabolism*
  • Humans
  • Isotretinoin / adverse effects
  • Isotretinoin / pharmacokinetics*
  • Isotretinoin / therapeutic use
  • Liver / metabolism
  • Maternal-Fetal Exchange*
  • Pregnancy


  • Isotretinoin