Prolonged remission induced by cyclosporine in a patient with familial thrombocytopenia and enteropathy

Pediatr Hematol Oncol. 1995 May-Jun;12(3):289-93. doi: 10.3109/08880019509029571.


A 21-year-old patient, since the age of 16, presented a familial type of chronic autoimmune thrombocytopenia that responded only partially to various types of immunosuppressive treatment. His prolonged survival, compared to his decreased siblings, was complicated by the appearance of a severe enteropathy. High doses of corticosteroids induced a type 1 diabetes as a major side effect. The introduction of cyclosporine resulted in both a continuous complete clinical remission and a partial hematological remission and allowed the discontinuation of all other medication for 18 months. In uncommon complex autoimmune disease, cyclosporine may represent a safe and effective alternate therapy when other immunosuppressive agents have failed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Autoimmune Diseases / drug therapy*
  • Common Variable Immunodeficiency / drug therapy
  • Cyclosporine / therapeutic use*
  • Humans
  • Intestinal Diseases / drug therapy*
  • Male
  • Thrombocytopenia / drug therapy*


  • Cyclosporine