Melkersson-Rosenthal syndrome

Semin Dermatol. 1995 Jun;14(2):135-9. doi: 10.1016/s1085-5629(05)80009-4.


Melkersson-Rosenthal syndrome is a triad of recurrent orofacial swelling, relapsing facial paralysis, and fissured tongue. However, the classic triad is not frequently seen in its complete form. Monosymptomatic and oligosymptomatic forms are more common. The histological findings of sarcoid-like granuloma in skin or mucosal biopsy specimens support the diagnosis. The course is chronic but benign. Treatment is difficult, but intralesional or systemic corticosteroids may be helpful.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Female
  • Humans
  • Melkersson-Rosenthal Syndrome* / diagnosis
  • Melkersson-Rosenthal Syndrome* / pathology
  • Melkersson-Rosenthal Syndrome* / therapy
  • Middle Aged
  • Skin / pathology