Human papillomavirus DNA and TP53 mutations in lung cancers from butchers

Br J Cancer. 1995 Aug;72(2):293-7. doi: 10.1038/bjc.1995.327.


To investigate whether the high frequency of human papillomavirus infection in butchers may be linked to their higher than average incidence of lung cancer, we have examined lung cancers from 40 butchers and 26 controls for the presence of DNA from both HPV type 7, which is found almost uniquely in hand warts from butchers and fishermen, and for those HPV types associated with laryngeal and genital cancers. No HPV 7, and only a low frequency of HPV DNA was found, suggesting that HPV infection does not make an important contribution to the elevated levels of lung cancer in meat handlers. In addition, the frequency of p53 mutation was shown to be slightly lower than previously reported in lung cancers.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Base Sequence
  • DNA, Viral / analysis*
  • DNA, Viral / genetics
  • Food Handling*
  • Genes, p53*
  • Humans
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / pathology
  • Lung Neoplasms / virology*
  • Male
  • Meat*
  • Middle Aged
  • Molecular Sequence Data
  • Mutation*
  • Occupational Diseases / genetics*
  • Occupational Diseases / pathology
  • Occupational Diseases / virology*
  • Papillomaviridae / genetics*
  • Polymerase Chain Reaction
  • Prevalence


  • DNA, Viral