Phenotype of glutathione S-transferase Mu (GSTM1) and susceptibility to malignant melanoma. MMM group. Multidisciplinary Malignant Melanoma Group

Br J Cancer. 1995 Aug;72(2):324-6. doi: 10.1038/bjc.1995.332.


The isoenzyme Mu of glutathione S-transferase (GSTM1) is dominantly inherited, and the prevalence of this isoenzyme in the population is about 60%. The lack of GSTM1 has been linked with cancer risk. The frequency of the phenotypes of this isoenzyme in melanoma (MM) patients (n = 197) is reported here. A significantly higher proportion of individuals in the control group (n = 147) had measurable GSTM1 than MM patients (59.1% vs 42%, P = 0.002); there was a higher proportion of positive phenotypes in general among women than among men. Odds ratio analysis indicated that individuals with this polymorphic variant have an approximately 2-fold risk of developing these cancers. GSTM1 phenotype distribution depends on age, smoking habit and tumour pathology. A group of MM patients with dysplastic naevi was also studied.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antioxidants / metabolism
  • Female
  • Glutathione Transferase / deficiency*
  • Glutathione Transferase / genetics*
  • Glutathione Transferase / metabolism
  • Humans
  • Isoenzymes / deficiency*
  • Isoenzymes / metabolism
  • Isoenzymes / physiology
  • Male
  • Melanoma / enzymology*
  • Melanoma / etiology
  • Middle Aged
  • Neoplasms, Radiation-Induced / enzymology
  • Neoplasms, Radiation-Induced / etiology
  • Phenotype
  • Reactive Oxygen Species / metabolism
  • Reactive Oxygen Species / toxicity
  • Reference Values
  • Risk Factors
  • Ultraviolet Rays / adverse effects


  • Antioxidants
  • Isoenzymes
  • Reactive Oxygen Species
  • Glutathione Transferase