Dystrophin and utrophin: the missing links!

FEBS Lett. 1995 Aug 1;369(1):27-33. doi: 10.1016/0014-5793(95)00398-s.


There is considerable sequence homology between dystrophin and utrophin, both at the protein and DNA level, and consequently it was assumed that their domain structures and functions would be similar. As more of the detailed biochemical and cell biological properties of these two proteins become known, so it becomes clear that there are subtle if not significant differences between them. We review recent findings and present new hypotheses into the structural and functional properties of the actin-binding domain, central coiled-coil region and regulatory/membrane protein-binding regions of dystrophin and utrophin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins / metabolism
  • Amino Acid Sequence
  • Cytoskeletal Proteins / physiology*
  • Dystrophin / physiology*
  • Extracellular Matrix / metabolism
  • Membrane Proteins / metabolism
  • Models, Biological
  • Molecular Sequence Data
  • Protein Binding
  • Protein Structure, Tertiary*
  • Sequence Homology, Amino Acid
  • Utrophin


  • Actins
  • Cytoskeletal Proteins
  • Dystrophin
  • Membrane Proteins
  • Utrophin