Role of heterotrimeric GTP binding proteins in vesicular protein transport: indications for both classical and alternative G protein cycles

FEBS Lett. 1995 Aug 1;369(1):84-8. doi: 10.1016/0014-5793(95)00620-o.


Heterotrimeric G proteins are involved in hormonal signal transduction across the plasma membrane. Recent evidence suggests that they have a role in vesicular protein transport as well. Biochemical probes that interfere with the classical G protein cycle have been applied to the field of intracellular membrane transport to study their mechanism of action. Evidence has been obtained that intracellular G proteins act both through classical and alternative G protein cycles.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biological Transport
  • Cell Membrane / metabolism*
  • Endocytosis / physiology
  • GTP-Binding Proteins / metabolism*
  • Guanosine Triphosphate / metabolism*
  • Intracellular Membranes / metabolism*
  • Models, Biological
  • Organelles / metabolism
  • Protein Conformation
  • Proteins / metabolism
  • Signal Transduction*


  • Proteins
  • Guanosine Triphosphate
  • GTP-Binding Proteins