Full-thickness macular holes treated with vitrectomy and tissue glue

Int Ophthalmol. 1994;18(6):355-8. doi: 10.1007/BF00930314.


In the surgical treatment of full-thickness macular holes good results have been published with the combination of vitrectomy, gas and application of Transforming Growth Factor beta 2. Other authors report a 73% success rate in closing a full-thickness macular hole after vitrectomy and gas tamponade alone. We used, in addition to vitrectomy and gas tamponade, a tissue glue to stimulate adhesion of the elevated cuff of neurosensory retina surrounding a full-thickness macular hole and to close to hole itself. A total of 15 eyes of 13 patients (3 men, 10 women), with stage 3 and 4 macular holes were operated. All of the 13 uncomplicated cases showed complete closure of the macular hole. In one case (8%) the visual acuity decreased one line in spite of a funduscopically closed hole, and in two cases (16%) visual acuity remained the same despite closure. Increased visual acuity was seen in ten cases (76%), eight of which improved more than two lines.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Combined Modality Therapy
  • Female
  • Fibrin Tissue Adhesive / therapeutic use*
  • Follow-Up Studies
  • Fundus Oculi
  • Humans
  • Male
  • Middle Aged
  • Retina / drug effects
  • Retina / pathology
  • Retina / surgery
  • Retinal Perforations / pathology
  • Retinal Perforations / surgery
  • Retinal Perforations / therapy*
  • Treatment Outcome
  • Vitrectomy*


  • Fibrin Tissue Adhesive