Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells

Mol Immunol. 1995 Jun;32(9):651-9. doi: 10.1016/0161-5890(95)00023-8.


The CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) molecules form a membrane heterodimer that is non-covalently associated with surface membrane immunoglobulin and is the major signaling component of the B cell antigen receptor complex. We have defined variant RNA transcripts for both CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) which appear to arise by alternative splicing. These splice variants are predicted to encode truncated forms of these molecules that result in the deletion of the entire extracellular Ig-like domain of CD79b and of a major portion of the extracellular domain of CD79a. The presence of these short transcripts in a variety of human B cells and B cell lines was established by an RNAse protection assay. The definition of these variant transcripts provides a basis for a continuing effort to define variant protein products of CD79a and CD79b and examine their role in B cell physiology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alternative Splicing
  • Amino Acid Sequence
  • Antigens, CD / genetics*
  • B-Lymphocytes / metabolism*
  • Base Sequence
  • CD79 Antigens
  • DNA Primers / chemistry
  • Humans
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • RNA, Messenger / genetics
  • Receptors, Antigen, B-Cell / genetics*
  • Sequence Alignment
  • Sequence Homology, Amino Acid


  • Antigens, CD
  • CD79 Antigens
  • CD79A protein, human
  • CD79B protein, human
  • DNA Primers
  • RNA, Messenger
  • Receptors, Antigen, B-Cell