Ventroposterior medial pallidotomy in patients with advanced Parkinson's disease

Neurosurgery. 1995 Jun;36(6):1112-6; discussion 1116-7. doi: 10.1227/00006123-199506000-00007.


In a preliminary study, the effects of ventroposterior medial pallidotomy were evaluated in five patients with advanced Parkinson's disease in whom medical therapy had failed. The mean age was 67.0 +/- 5.6 years, and the mean Hoehn and Yahr stage when "off" was 3.9 +/- 1.3. Three patients received unilateral pallidotomies; two of these received another pallidotomy after 8 weeks. Two other patients received staged bilateral pallidotomies. No significant differences in overall function could be seen before and after the first surgical procedure. All three patients with peak-dose dyskinesias or dystonia had marked contralateral reduction in these symptoms. Ventroposterior medial pallidotomy can ameliorate peak-dose dyskinesias in patients with advanced Parkinson's disease. Overall function improvement is not remarkable.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antiparkinson Agents / administration & dosage
  • Antiparkinson Agents / adverse effects
  • Combined Modality Therapy
  • Dominance, Cerebral / physiology
  • Dose-Response Relationship, Drug
  • Female
  • Globus Pallidus / physiopathology
  • Globus Pallidus / surgery*
  • Humans
  • Male
  • Middle Aged
  • Neurologic Examination / drug effects
  • Parkinson Disease / physiopathology
  • Parkinson Disease / surgery*
  • Reoperation


  • Antiparkinson Agents