Recurrent nasopharyngeal tumors: preliminary clinical results with interventional MR imaging--controlled laser-induced thermotherapy

Radiology. 1995 Sep;196(3):725-33. doi: 10.1148/radiology.196.3.7644636.


Purpose: To evaluate magnetic resonance (MR) imaging-controlled laser-induced thermotherapy (LITT) in the treatment of recurrent head and neck tumors.

Materials and methods: Six patients with recurrent nasopharyngeal tumors (squamous cell carcinoma [n = 4], pleomorphic adenoma [n = 2]) underwent LITT with local anesthesia. A 7-F introducing sheath was inserted into the center of the tumor followed by a specially designed laser emitter. Therapy was monitored on-line with MR thermometry, and the amount of necrosis was estimated with dynamic and static contrast material-enhanced sequences.

Results: All procedures were well tolerated with use of local anesthesia, with no clinically relevant side effects. MR thermometry depicted up to 15-mm-diameter areas of less signal intensity near the laser tip. Coagulative necrosis was achieved in all patients (volume range, 4-28 cm3), and clinical symptoms were reduced in four.

Conclusion: MR imaging-controlled LITT may be a safe, minimally invasive alternative in the treatment of recurrent head and neck tumors.

MeSH terms

  • Adenoma, Pleomorphic / therapy
  • Anesthesia, Local
  • Carcinoma, Squamous Cell / therapy
  • Catheterization / instrumentation
  • Combined Modality Therapy
  • Contrast Media
  • Equipment Design
  • Female
  • Follow-Up Studies
  • Humans
  • Hyperthermia, Induced* / instrumentation
  • Laser Coagulation* / instrumentation
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Monitoring, Physiologic
  • Nasopharyngeal Neoplasms / therapy*
  • Necrosis
  • Needles
  • Neoplasm Recurrence, Local / therapy*
  • Online Systems
  • Radiology, Interventional*
  • Tomography, X-Ray Computed


  • Contrast Media