Brain lesions in patients with multiple sclerosis: detection with echo-planar imaging

Radiology. 1995 Sep;196(3):765-71. doi: 10.1148/radiology.196.3.7644641.


Purpose: To evaluate the detection of brain lesions with echo-planar imaging relative to conventional spin-echo (SE) imaging.

Materials and methods: In 17 patients (three men, 14 women; mean age, 31 years) with multiple sclerosis, the following were compared: single-shot proton-density- and T2-weighted and thin-section T2-weighted echo-planar, proton-density- and T2-weighted multishot echo-planar, and conventional SE sequences. Quantitative and qualitative criteria as well as lesion detectability were evaluated. The proton-density-weighted SE sequence was used as the standard of reference.

Results: Multishot sequences were superior to single-shot sequences in image quality and lesion detectability. With the multishot proton-density-weighted sequence, 53 of 54 large lesions and 23 of 30 small lesions were detected; with the single-shot proton-density-weighted sequence, 38 of 54 large lesions and five of 30 small lesions were detected.

Conclusion: With multishot echo-planar sequences, detectability of large lesions is similar to that with conventional SE imaging. Susceptibility artifact is diminished in comparison to single-shot echo-planar sequences.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Artifacts
  • Brain Diseases / diagnosis*
  • Brain Diseases / pathology
  • Cerebellar Diseases / diagnosis
  • Cerebellar Diseases / pathology
  • Echo-Planar Imaging* / methods
  • Female
  • Humans
  • Image Enhancement / methods
  • Magnetic Resonance Imaging / methods
  • Male
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / pathology
  • Prospective Studies
  • Sensitivity and Specificity
  • Signal Processing, Computer-Assisted