Correlation of dynamic responses in the ON bipolar neuron and the b-wave of the electroretinogram

Vision Res. 1995 May;35(10):1359-64. doi: 10.1016/0042-6989(95)98715-l.


2-Amino-4-phosphonobutyrate (APB) is known to selectively suppress the light response of ON bipolar cells in the vertebrate retina, and reduce the b-wave of the electroretinogram (ERG) as a consequence. Using slow drug application, the progressive effect of APB was used to compare the relative response amplitudes of the b-wave and the ON bipolar cell. Simultaneous ERG recordings and ON bipolar intracellular recordings were performed in the amphibian retina. The results indicate that there is a strong positive correlation between these two waveforms. This supports the possibility that the b-wave of the ERG is the direct result of ON bipolar cell activity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Ambystoma
  • Aminobutyrates / pharmacology
  • Animals
  • Culture Techniques
  • Electroretinography* / drug effects
  • Neurons, Afferent / drug effects
  • Neurons, Afferent / physiology*
  • Photic Stimulation
  • Retina / drug effects
  • Retina / physiology*


  • Aminobutyrates
  • 2-amino-4-phosphonobutyric acid