Vitamin D and prostate cancer

Adv Exp Med Biol. 1995;375:53-63. doi: 10.1007/978-1-4899-0949-7_5.

Abstract

Our findings demonstrate the presence of VDR in various human prostate cancer cell lines and in primary cultures derived from normal, BPH and prostate cancer. In addition, 1,25-D induced several bioresponses in these cells including growth inhibition and PSA stimulation. Based on examples in many different malignant cells as well as our data in prostate cells, that vitamin D is anti-proliferative and promotes cellular maturation, it seem clear that vitamin D must be viewed as an important cellular modulator of growth and differentiation if addition to its classical role as regulator of calcium homeostasis. In this respect, vitamin D has the potential to have beneficial actions on various malignancies including prostate cancer. Its ultimate role in prostate cancer remains to be determined, but 1,25-D may prove useful in chemoprevention and/or differentiation therapy. We believe the data currently available provide the basis for an optimistic view on the possible use of vitamin D to treat prostate cancer in patients and that further investigation is clearly warranted to better define its potential therapeutic utility.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Calcitriol / analogs & derivatives
  • Calcitriol / pharmacology
  • Cell Division / drug effects
  • Humans
  • Male
  • Prostatic Neoplasms* / epidemiology
  • Prostatic Neoplasms* / etiology
  • Prostatic Neoplasms* / pathology
  • Receptors, Calcitriol / physiology
  • Tumor Cells, Cultured
  • Vitamin D / pharmacology
  • Vitamin D / physiology*

Substances

  • Receptors, Calcitriol
  • Vitamin D
  • Calcitriol