Taxol inhibits growth of mesothelioma xenografts

Anticancer Res. 1995 May-Jun;15(3):693-6.

Abstract

Background: In vitro tests measuring inhibition of adenosine triphosphate activity predicted three mesothelioma xenografts would be sensitive to taxol.

Purpose: The in vivo therapeutic efficacy of taxol was tested in nude mice carrying the subcutaneous tumors.

Methods: Once tumor growth reached 100mm3 in size, intraperitoneal taxol, 30 mg/kg, on a day 1, 4, and 8 schedule, was administered to mice bearing subcutaneous mesothelioma xenografts.

Results: Taxol inhibits the growth of all three cell lines. It produces actual tumor regression including some complete responses.

Conclusions: Taxol is an active drug against mesothelioma. The in vitro cell lines and the in vivo system are useful tools for screening and developing new treatments for mesothelioma.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cell Division / drug effects*
  • Cell Line
  • Female
  • Humans
  • Mesothelioma / drug therapy
  • Mesothelioma / pathology*
  • Mice
  • Mice, Nude
  • Paclitaxel / pharmacology*
  • Paclitaxel / therapeutic use
  • Time Factors
  • Transplantation, Heterologous
  • Tumor Cells, Cultured

Substances

  • Paclitaxel