Heterogeneity of myocardial blood flow

Basic Res Cardiol. Mar-Apr 1995;90(2):103-11. doi: 10.1007/BF00789440.


Myocardial blood flow is heterogeneous, whether considered by chamber, by layers of the ventricular walls, or by microregions within layers. There is also variability of myocardial flow reserve, particularly in layers and microregions, even when the heart is arrested. The variability of flow during arrest may be associated with the resistance pathways to each region, but the variability of flows in the beating heart with vascular tone is probably due to regional differences in work and thus oxygen demand. Heterogeneity by layer may be responsible for the subendocardial ischemia that is common to many forms of heart disease. Microheterogeneity may account for the patchy necrosis that occurs with chronic ischemia.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Atrial Function
  • Blood Flow Velocity
  • Coronary Circulation / physiology*
  • Humans
  • Regional Blood Flow / physiology
  • Time Factors
  • Ventricular Function