The acute respiratory distress syndrome

N Engl J Med. 1995 Jan 5;332(1):27-37. doi: 10.1056/NEJM199501053320106.


ARDS is a complex response of the lung to direct (inhalational) and indirect (hematogenous) insults. It is easy to be pessimistic about the benefit of the approaches we have described, but there is evidence that overall survival has improved in recent years. To maintain this progress, new therapies for ARDS must be rigorously evaluated, and their routine use should be recommended only after careful scrutiny of the evidence. Such a course will eliminate the unnecessary risks and costs often associated with unproved therapies.

Publication types

  • Review

MeSH terms

  • Humans
  • Positive-Pressure Respiration
  • Respiration, Artificial
  • Respiratory Distress Syndrome / diagnosis*
  • Respiratory Distress Syndrome / drug therapy
  • Respiratory Distress Syndrome / therapy*