Psychosis in Apert's syndrome with partial agenesis of the corpus callosum

J Psychiatry Neurosci. 1995 Jul;20(4):307-9.


A 19-year-old male with Apert's syndrome developed psychotic symptoms that responded to haloperidol. He was also found to have partial agenesis of the corpus callosum and enlarged lateral ventricles on a head CT scan. The implications of these findings in the context of psychotic symptoms are discussed. There are no previous reports of psychosis in patients with Apert's syndrome.

Publication types

  • Case Reports

MeSH terms

  • Acrocephalosyndactylia / diagnosis*
  • Acrocephalosyndactylia / physiopathology
  • Acrocephalosyndactylia / psychology
  • Adult
  • Agenesis of Corpus Callosum*
  • Cerebral Ventricles / pathology
  • Corpus Callosum / pathology
  • Corpus Callosum / physiopathology
  • Haloperidol / therapeutic use
  • Humans
  • Male
  • Neurocognitive Disorders / diagnosis*
  • Neurocognitive Disorders / physiopathology
  • Neurocognitive Disorders / psychology
  • Tomography, X-Ray Computed


  • Haloperidol