Cyclins, CDKs and cancer

Semin Cancer Biol. 1995 Apr;6(2):63-72. doi: 10.1006/scbi.1995.0009.


The connections between cancer and the basic machinery of the cell cycle have taken a surprisingly long time to become apparent. However, the past 2 years has seen a dramatic increase in the number of cell cycles regulators that have been implicated as either protooncogenes or as tumour suppressor genes. In this review I will attempt to show how perturbations in the known cell cycle regulators may play a part in the process of oncogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology
  • Cyclin-Dependent Kinases / metabolism*
  • Cyclins / physiology*
  • Humans
  • Neoplasms / etiology*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Oncogenes
  • Proto-Oncogenes


  • Cyclins
  • Cyclin-Dependent Kinases