Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22

Nat Genet. 1995 May;10(1):41-6. doi: 10.1038/ng0595-41.


We have performed linkage analysis in 186 multiplex families to search for genes that predispose to schizophrenia. Under a model with partially dominant inheritance, moderately broad disease definition and assuming locus homogeneity, a lod score of 3.2 was obtained for D6S260 on chromosome 6p23. A multipoint lod score of 3.9 (P = 2.3 x 10(-5)) was achieved when the F13A1 and D6S260 loci were analysed, allowing for locus heterogeneity. Adjusted for testing of multiple models, the multipoint lod score of 3.9 under heterogeneity has a genome wide significance of between 5-8%. The nonparametric affected pedigree member test provided results (P = 3 x 10(-4)) also supporting this finding. Our findings provide supportive evidence for a susceptibility locus for schizophrenia on distal chromosome 6p, and support a model of locus heterogeneity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosomes, Human, Pair 6*
  • DNA, Satellite
  • Female
  • Genetic Heterogeneity
  • Genetic Linkage
  • Genetic Markers
  • Humans
  • Lod Score
  • Male
  • Schizophrenia / genetics*


  • DNA, Satellite
  • Genetic Markers