Localization of a gene for partial epilepsy to chromosome 10q

Nat Genet. 1995 May;10(1):56-60. doi: 10.1038/ng0595-56.


There is strong evidence for a genetic contribution to epilepsy, but it is commonly assumed that this genetic contribution is limited to 'generalized' epilepsies, and that most forms of 'partial' epilepsy are nongenetic. In a linkage analysis of a single family containing 11 affected individuals, we obtained strong evidence for localization of a gene for partial epilepsy. This susceptibility gene maps to chromosome 10q, with a maximum two-point lod score for D10S192 of 3.99 at theta = 0.0. All affected individuals share a single haplotype for seven tightly linked contiguous markers; the maximum lod score for this haplotype is 4.83 at theta = 0.0. Key recombinants place the susceptibility locus within a 10 centimorgan interval.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Chromosome Mapping
  • Chromosomes, Human, Pair 10*
  • Epilepsies, Partial / genetics*
  • Female
  • Genetic Linkage
  • Genetic Markers
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Pedigree


  • Genetic Markers