Insulin resistance and lipoprotein metabolism

Curr Opin Lipidol. 1995 Jun;6(3):153-60. doi: 10.1097/00041433-199506000-00007.

Abstract

Dyslipidaemia in insulin resistance comprises elevated plasma triglycerides, decreased HDL, a preponderance of small, dense LDL and increased postprandial lipaemia. In terms of cause and effect, small, dense LDL, alimentary hyperlipidaemia and changes in HDL are consequences of elevated triglycerides. These abnormalities can become frequent if triglycerides exceed a threshold value of approximately 1.5 mmol/l. Therefore, it is mandatory to maintain plasma triglycerides as low as possible in noninsulin-dependent diabetic and insulin-resistant individuals to prevent the potentially atherogenic and metabolic consequences of hypertriglyceridaemia.

Publication types

  • Review

MeSH terms

  • Aging / blood
  • Female
  • Humans
  • Hyperlipidemias / physiopathology
  • Insulin Resistance / physiology*
  • Lipoproteins / blood*
  • Male
  • Plasminogen Activator Inhibitor 1 / blood
  • Risk Factors
  • Sex Characteristics
  • Triglycerides / physiology*

Substances

  • Lipoproteins
  • Plasminogen Activator Inhibitor 1
  • Triglycerides