A TH1-TH2-like switch in candidiasis: new perspectives for therapy

Trends Microbiol. 1995 Jun;3(6):237-40. doi: 10.1016/s0966-842x(00)88931-3.


An imbalance in TH1-type and TH2-type responses may allow Candida albicans to modify the host response to favor its own persistence. This hypothesis has important consequences for allergy, autoimmunity and co-infection, and also highlights a potential role for cytokine and anti-cytokine therapy in Candida-related pathology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Candida albicans / immunology
  • Candidiasis / drug therapy
  • Candidiasis / immunology*
  • Cytokines / antagonists & inhibitors
  • Cytokines / immunology
  • Cytokines / therapeutic use
  • Humans
  • Immune Tolerance
  • Th1 Cells / immunology*
  • Th2 Cells / immunology*


  • Cytokines