Murine model of anterior and posterior ocular melanoma

Curr Eye Res. 1995 May;14(5):399-404. doi: 10.3109/02713689508999938.


Iris melanomas are less likely to metastasize than ciliary body or choroidal melanomas. In order to study this difference in metastatic rate, we developed a murine model of anterior chamber (AC) and posterior compartment (PC) melanoma. Eighteen C57BL6 mice were inoculated in the AC (n = 6) or PC (n = 12) with B16F10 melanoma cells and eleven mice were inoculated in the AC (n = 3) or PC (n = 8) with Queens melanoma cells. The animals were sacrificed at 12 to 14 days post inoculation and histologically examined. Results were that 8 of 9 AC tumors and 10 of 20 PC tumors grew. One PC tumor metastasized to the lungs. This model may be used to study anterior versus posterior ocular melanoma differences.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Anterior Chamber
  • Choroid Neoplasms / pathology*
  • Ciliary Body / pathology*
  • Disease Models, Animal
  • Female
  • Iris Neoplasms / pathology*
  • Lung Neoplasms / secondary*
  • Melanoma, Experimental / pathology
  • Melanoma, Experimental / secondary*
  • Mice
  • Mice, Inbred C57BL
  • Uveal Neoplasms / pathology*