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Review
, 369 (2-3), 136-9

Nitric Oxide Regulates Mitochondrial Respiration and Cell Functions by Inhibiting Cytochrome Oxidase

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Review

Nitric Oxide Regulates Mitochondrial Respiration and Cell Functions by Inhibiting Cytochrome Oxidase

G C Brown. FEBS Lett.

Abstract

Nitric oxide (NO) reversibly inhibits mitochondrial respiration by competing with oxygen at cytochrome oxidase. Concentrations of NO measured in a range of biological systems are similar to those shown to inhibit cytochrome oxidase and mitochondrial respiration. Inhibition of NO synthesis results in a stimulation of respiration in a number of systems. It is proposed that NO exerts some of its main physiological and pathological effects on cell functions by inhibiting cytochrome oxidase. Further NO may be a physiological regulator of the affinity of mitochondrial respiration for oxygen, enabling mitochondria to act as sensors of oxygen over the physiological range.

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