Abstract
Mammalian voltage-activated Shaker K+ channels associate with at least three cytoplasmic proteins: Kv beta 1, Kv beta 2 and Kv beta 3. These beta subunits contain variable N-termini, which can modulate the inactivation of Shaker alpha subunits, but are homologous throughout an aldo-keto reductase core. Human and ferret beta 3 proteins are identical with rat beta 1 throughout the core while beta 2 proteins are not; beta 2 also contains a shorter N-terminus and has no reported physiological role. We report that human beta 1 and beta 3 are derived from the same gene and that beta 2 modulates the inactivation properties of Kv1.4 alpha subunits.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alternative Splicing*
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Amino Acid Sequence
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Animals
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Base Sequence
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Brain / metabolism*
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Cattle
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Conserved Sequence
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DNA Primers
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Female
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Ferrets
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Gene Expression
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Hominidae / genetics*
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Humans
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Macromolecular Substances
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Mammals
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Membrane Potentials / physiology
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Molecular Sequence Data
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Myocardium / metabolism
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Oocytes / physiology
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Peptide Biosynthesis*
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Peptides / genetics*
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Polymerase Chain Reaction
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Rats
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Sequence Homology, Amino Acid
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Shaker Superfamily of Potassium Channels
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Transfection
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Xenopus laevis
Substances
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DNA Primers
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Macromolecular Substances
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Peptides
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Shaker B potassium channel polypeptide
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Shaker Superfamily of Potassium Channels
Associated data
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GENBANK/U33428
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GENBANK/U33429